If God is so kind , he could have kept HDL around 130 to 160mg and LDL to be around 30 to 50 mg.
Why he hasn’t done that ?
Is he so unfriendly to human beings ? Our intellect really believed so.. Since God has not addressed this issue , we decided to work against his wish, and tried to reverse the molecular harm with a variety of molecular weapons to bring down the LDL closer to HDL. The enlightened thinking is, if LDL and HDL are brought around the same level of around 50mg , good and evil will have level playing ground , hoping goodness will win over the evil .Our vast vascular tree will have perfect lipid house keeping system and atherosclerosis will cease to occur.( Some even thought we can altogether kill the LDL and make it zero!)
Nature (God) has created every molecule with a dedicated function. Labelling of cholesterol as Good and bad , are immature scientific conclusions. No molecule is bad or good when looked at a overall sense of body homeostasis . Of course, body do have toxic molecules that are periodically excreted on moment to moment , or day to day basis by respective systems. Lipid metabolism also has regulatory system in place. However, the lipid -endothelium interactions are too complex .
Can any one believe this as truth, that there is little correlation between circulating blood lipids with arterial plaque lipids ? It is for the sake of simplicity we used term good and bad lipids that has become a false fact. It is worth noting the attractive option of raising good HDL by means of drugs proved disastrous to the vascular endothelium. Also mind ,if HDL exceeds 60mg it starts injuring the cells.
Final message.
Remember ,there is no intravascular war going on between good and bad cholesterol . Please realize both molecules are good and exists for some specific purpose. In perfect health, there is never a hurry to tamper the harmonious body by drugging them with sophisticated new molecules loaded with unknown good and harm . (Does it remind the famous Osler’s quote,? If Sir Osler tells the same quote now ,he is definitely at risk of heavily trolled even by the academia)
Post-amble
In coming decades we can expect a barrage of anti LDL weaponry working at the level of small interfering or micro RNAs, within the cells. As I am writing this on October 7th , 2024 Nobel prize is being given to Victor Ambros and Gary Ruvkun, the team from UK & USA discovery of micro RNA .Congratulations.
Dr.S.Venkatesan MD 
