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Dr.S.Venkatesan MD

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A reality check on coronary hemodynamics : How is this possible ? 

March 8, 2025 by dr s venkatesan

How do you explain this ? 99% occlusion still TIMI 3 flow ?

Answer

A. It could be a parallax error. Lesion may not be tight. Should be seen in other views.

B . Forcible Injection by the operator, make it an artificial TIMI -3 flow.

C .Such flows are very much possible .It Indicates a healthy distal micro-circulation a vascular bed in a fully dilated mode.

D. TIMI flow is not reliable here . We need TIMI frame count to confirm.

Follow up questions

1.How much will be the FFR ?

Likely to be less than . 8 definitely , but surprises can happpen

2.Can he be asymptomatic ?

Unlikely.

Final message

Coronary occlusions are ominpresent . While we have mastered the art of successfully taming these anatomical enemies , we are still very much ignorant what these lesions actually do, to the physiology, inspite of half a dozen flow reserve Indices we have.(FFR,iFR, rFR,qFR, dP/dT ,etc)

The question is, at what level of obstruction, it really limits the coronary bllod flow significantly ( both at rest and exertion) . One thing is clear , it is higly variable & Individualistic, the secrets of which lies deep, in the domain of invisible micro-vascular network integrity.

Counterpoint

TIMI flows may no longer be valid in non-ACS situations. The name TIMI , by itself carries flow after thrombolysis. For some unexplained (& debatable ) reasons, we are used to apply this flow grade , in every angiographic flow scenerios irrespective of underlying clinical entity.

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Posted in Uncategorized | Tagged coronary auto regulation, coronary hemodynamics, cr qfr, ffr ifr qfr, flow limiting lesion, micro vascular circulation, non flow limiting lesion, timi flow, timi frame count |

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