Beta blocker use in cardiac failure has come a full circle from a “contraindication to indication”
You don’t need gimmicks of statistics for science to progress. What you require is meticulous observation.
F .Waagstein of Sweden just did this with a study population of seven patients .
This land mark study , was least significant statistically , but most significant clinically
Today , as on 2009 , if any one submits a manuscript of a study to a journal , done with seven patients he or she will be called as a fool ! BMJ , in 1975 had a courage in not doing so and thus a break through concept was born.
So young scientists , should not get bothered about sophisticated statistical method.
Science is not about number gimmicks it is about truth and nothing but truth ! Truths may come out from single digit study or even a single patient study
Dr.S.Venkatesan MD 
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