Infective endocarditis remains a major cardiac emergency.
Medical management has an initial role and the many will require some form of surgery
( Mainly valve replacement). But the surgeons request a realtively stable patients to operate upon as
surgical mortality is high in patients with uncontrolled infection and destabilsed CHF.
Even though there are battery of antibiotics, and volumes of texts written on the medical management
of infective endocarditis the medical therapy fails in bulk of the patients.
We have observed emprical (Scientific guess work ) therapy has helped many patients .
While rifampicin according to scientific worls it’s useful only in prosthetic valve endocardtis
we have found it quiet useful in all resistant IE patients.
IE being a chronic inflammatory state rifampicin might work
also as an anti inflammatory or immune modulator.
This paper was presented in Cardiological society of India , Annual scientific sessions at Mumbai 2005 . Download PPT
Dr.S.Venkatesan MD 
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