This article is from the journal JAMA July 2011 , and “The Telegraph” breaks the News in general media because of the immense importance it has for the public.
HMG COA reductase has a new side effect when used in high doses. It is now official , it is confirmed by this meta analysis.
According to this study the risk is mainly with 80mg of Atrovastatin . But the dose at which the diabetic risk develops is highly variable.
In simple terms . . . It all depends upon how a person’s liver responds to ingested statins.
Statins are not divine molecules that can heal atherosceloris. It mercilessly blocks the vital cholesterol synthesizing enzyme HMG COA* located in every cell , especially it has a virulent action in the hepatocytes . We know liver is the major metabolic hub which co ordinates glucose and Lipid metabolism and to certain extent amino acids as well . These statin infested hepatocytes can interfere with glycolysis , neo-glucogenesis and lipolysis in a complex fashion . It would not require great brains to understand how diabetes can be induced by statins !
* Which also has a indirect cell/ lipid servicing action.
It is becoming increasingly clear , statins should be used judiciously in whatever dose . We need to be in constant vigil even as the human lipid is under siege from the corporate board rooms , who are primarily worried about the decline in the per capita consumption of these ubiquitous molecule !