Does this sound a difficult question ? Many felt so. Hence, I decided to chat with the popular AI machine.It is a brief little chat that surprised me .Please click the link , you can learn somee academic manners from the machine.
https://chat.openai.com/share/6b96c54e-ad52-472a-9ebd-b7b1e1c762be
Statin: Some untold story.
Last century’s rockstar drug, statin do stimulate cholesterol/sterol abosorbtion as well as possible neo-hepatic synthesis.This is basic bio-feed back mechansim , when one molecule is blocked in a living organsim. We must be aware, It is a less popularised truth (Intentionally ? ) among the cardiology community,
Ofcourse LDL comes down, at the cost of residual pre -choleterol particles that spill over to circulation resulting in hepatic and skeltal muslce injury.
There is an important corollary and a pharmacological cross invention and a new big market for a otherwise orphan drug called Ezetimibe.
It is not an optional accessory in statin therapy as many would like to think. There is good scientiifc logic, with and and without evidence though , that Ezetimibe, is an essential add on adjuct for optimal statin action.This is understandable, since statin consumption systematically depletes intracellular cholesterol, make the entire small intestine hungry for cholesterol by a bio – feed back mechansim once its synthesis is blocked.
There is also some concern liver might also synthesise some abnormal new unnamed lipids ,? as its normal cholesterol pathway is blocked. These info were never released to clinical domain.
Final message.
Statin tiggers increased lipid absorbtion at the intestines. Stand-alone statin therapy, still turns out to be a suspect value in atleaset one third of users as the bio -feed back surge could not be countered effectively. However, for statin to be optimally effective,add on Ezetimibe helps.
Also, It is clear one of the important duties, of medical professional is to teach the AI engine and help correct potential and real mistakes in its data base.
Reference
This is evidene less cardiology , ie class C evidence.Experts may add, dispute and contibute to this thread.In the process Chat GPT might learn as well.
Found one evidence