Posts Tagged ‘sitaxsentan’

Bosentan an non selective endothelin  antagonist is an approved drug  for pulmonary arterial hypertension.

Even this drug has not fully proven it’s worth . Meanwhile ,  a relatively  unknown company manufactured sitaxentan a similar molecule with a  self claimed  selective endothelin blocking property .

Pfizer bought this company and marketed it as Thelien . The liver injury is less  than bosentan , they claimed and it was  prescribed once a day .The same old story unfolds.physiological endothelin  in liver was in appropriately blocked and caused dangerous forms of liver injury.

Only one difference this time , Pfizer self banned this drug and stopped all research activities  about this molecule.


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