In thrombolysis of STEMI , there is a less published , but interesting observation . It is often noted , variation in the efficacy of streptokinase according to the time it was administered.It was most effective in the evenings and least effective in the early morning hours. The mechanism is thought to be due to , pineal gland driven endocrine spikes , that result in a less pronounced progoagulant activity in the evening hours. There could be a therapeutic significance for this phenomenon.
The following paper was presented as an abstract in the cardiological society of India annual scientific sessions in New Delhi in 1999.
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Dr.S.Venkatesan MD 
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