How does beta blocker acts as an anti anginal agent ?
June 28, 2013 by dr s venkatesan
Even though multiple mechanisms operate the major mechanism is due to augmentation and diversion of blood flow towards sub endocardial region* which is main area of ischemia in most patients with Angina .
*Beta blockers does this by smoothing the myocardial contractility there by reducing trans-myocardial gradient. The coronary arterial perforators which traverse from epicardium to endocardium gets less squeezed and promotes sub endocardial perfusion.
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