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LIMA-Left internal mamary  artery is the most common arterial  graft used in CABG.It is anastomosed with LAD /and or diagonal artery. Routine visualisation of LIMA is advocated by many , but it is required only  in patients with critical CAD.

LIMA angiogram is done

  1. To confirm the presence of LIMA .
  2. To exclude subclavian  stenosis.(If present hand can steal blood from heart !)
  3. To rule out disease of LIMA (Which is unlikely )
  4. Diameter of LIMA should be matched with LAD .LIMA with large lumens can accelerate restenosis in LAD due excess flow induced endothelial reaction
  5. To identify  any early branching of LIMA .This can divert the  blood flow and underperfuse LAD.
  6. Terminal bifurcation  of LIMA can some times be used as a sequential graft to LAD/LCX/OM
  7. Tortuosity and looping of  LIMA is common but generally has no hemodynamic significance.
  8. LIMA may  provide vital  nutritional support to sternum through direct or   intercostal branches .If  LIMA dependent sternal  blood supply is found to be significant ,   sufficient precautions to be taken and anticipate sternal ischemia related complications.This is especially important in diabetic subjects.

Bosentan an non selective endothelin  antagonist is an approved drug  for pulmonary arterial hypertension.

Even this drug has not fully proven it’s worth . Meanwhile ,  a relatively  unknown company manufactured sitaxentan a similar molecule with a  self claimed  selective endothelin blocking property .

Pfizer bought this company and marketed it as Thelien . The liver injury is less  than bosentan , they claimed and it was  prescribed once a day .The same old story unfolds.physiological endothelin  in liver was in appropriately blocked and caused dangerous forms of liver injury.

Only one difference this time , Pfizer self banned this drug and stopped all research activities  about this molecule.

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American journal of epidemiology in a land mark analysis has found , spouses share the same profile of coronary risk factors .This is a huge finding , considering the fact that , genetic factors are not involved here . So , it is something to do with family diet ? domestic issues, sibling effect ?

It is well-known lipid profile of family members are comparable . There are many Indian families who have high basal triglycerides .Mind you, husband and wife is the least (Zero link) linked genetically for familial dyslipidemia ,still they often share a similar lipid profile

Related issues without answers !

When a spouse gets a coronary event what are the chances of other to develop an event ?

Any body’s guess

In this era of bi- polar family life, can spouse behavior /unrest be a coronary risk factor ?

Yes . No surprises here .Apart form passive domestic smoking which is a well established coronary risk factor , in our coronary care unit , an initial survey of acute coronary syndrome patients revealed , a recent quarrel with their spouses, was a potential trigger for ACS. Further analysis of these data is being done

Spouse Ego : A powerful health risk

Spouse Ego : A powerful health risk

Divorce and coronary events ?

These are hypothetical observations in few families we have come across .

  • Forced divorce can be a definite coronary risk factor
  • Consensual divorce is not .
  • Women seeking divorce is more a risk for men than they inflict on women

Reference
Augusto Di Castelnuovo and others, Spousal Concordance for Major Coronary Risk Factors: A Systematic Review and Meta-Analysis, American Journal of Epidemiology, Volume 169, Issue 1, 1 January 2009, Pages 1–8, https://doi.org/10.1093/aje/kwn234

It was those great  years  1974 -1976.  Even before the concept of  PTCA was born, few  committed cardiologists  of New  Orleans were on a mission. Closing the ASD in cath lab. They  achieved it successfully with a umbrella device.

 

But 35 years later as on 2010 ,the concept though proven still struggles to prove itself.

Link to related article .

In any field  , errors and mistakes  transform into   experience in retrospect. (Of course only  if we  realize  our mistakes !) . Many would argue prevention of such errors is the  only way to move  forward in science  , but ,the opposite could also be true.

In Medicine ,

  • Most errors are mild ,
  • Some errors  can   be fatal but it helps us prevent further fatalities.
  • Some errors create history  and  re-define the science.

That’s   what  happened on 1958 , to be precise on  October  3oth , 1958  in a lonely laboratory of Henry  Ford hospital/Cleveland clinic *

*A correction -This  invention actually happened in Cleveland.  ( Sones learnt  all his techniques in Henry ford)

When  Sones along  with his assistant were trying  to do an  Aortogram in a patient with RHD,  the entire dye meant for aorta went straight  into  the right coronary artery.When every one was stunned ,the  patient happily  survived the injection  with a few skipped beats.

The man behind  this horrendous medical mistake was   Mr . Sones . He   was guilty for many days ,  spent many sleepless nights  ( In spite of  the patient surviving  the episode ). In fact , he was much amused  about the patient’s  survival . At that point of time,  even a spill over of dye into coronary artery was considered forbidden.  He pondered over the incident for months  .

Had  two queries  lingering in his mind .

  1. How the  right coronary artery  was able to withstand the 40cc dye  injected with  force .
  2. If 40 m l was tolerated ,  well what about routinely injecting  3-5 ml for visualizing the coronary  tree   by intentionally  seeking the coronary ostium .

That was the moment , the concept of diagnostic coronary  angiogram  was born . He published his observation as an  abstract in Circulation journal. Later he did many experiments  with video  engineering at Kodak labs , X  ray  technology to improve the cine imaging .By 1964 , he devised a perfect protocol  for doing  selective coronary angiogram. Then along with Rene Favaloro he pioneered CABG surgery in USA.

Final message

Cardiac  catheterisation was invented by  Forssman , Cournand , and Richards ,(Nobel prize 1956 ). It was  Sones who took it into the coronary arteries  and thus it was  made possible  for a whole new specialty  of coronary  diagnostics  and therapeutic PCI  which was  conceptualized by another extraordinary human life called   Gruentzig. Sones along with Gruentzig definitely deserve a Nobel in medicine which i think will happen soon ! They lived a great life constantly thinking, innovating  putting  patients interest in the fore front .

Mean while , I argue our youngsters  to  portray  the images of  these giants in  every   cath lab they  work   .You may get their blessings from heaven  , provided you do your interventions with integrity and honesty without any conflict of interest in the patient care.

Do not cry foul when some genuine errors happen in cath lab.Few among us (like Sones ) may innovate those mistakes into glory !

Reference

http://en.wikipedia.org/wiki/F._Mason_Sones#cite_note-3

http://www.wired.com/thisdayintech/2009/10/1030first-coronary-angiogram/

This one is from Cleveland clinic in their CCJM 2009.  It answers all those tricky questions when we plan   anti – coagulation in  pregnant women .

  • Should heparin substitution/bridge   always necessary  during  pregnancy  ?
  • When is warfarin safe  pregnancy ?
  • Simple  cessation of warfarin around  the time of labor and resuming  it after delivery  (Without heparin  substitution  )  Is it an option ?
  • How safe is LMWH in pregnancy ?

 

The ultimate reference article 
on peri-operative anticoagulation

 

It is often said medical   professionals lack engineering sense and vice versa. The filed of bio medical  engineering is is not  a new one . It is  there for over 50 years .The gap is narrowing very fast.

We are in the era of developing hybrid imaging , where a PET and CT come together. Raman spectroscopy is sending live  images of tissue histology from the coronary arteries .

A  journal exclusively catering to the cardiovascular enginnering is new development . Let us thank to the unique initiative from Purdue university .

Cadiac resynchrnonisation (CRT) therapy , is  the most famed  as well as  ridiculed treatment modality for refractory failure . It is facing a real tough time for survival now .(At least in class 4 CHF.)

Confident and  authentic data  are emerging  now , that CRT should not be  used  in advanced heart failure .(This is in total contrast with the original concept  ,  when CRT was introduced nearly  a decade ago !  more  of class 3 and 4 were enrolled ) . Bad outcomes are expected in advanced CHF. This is something similar to whipping the tired horse concept  which  found inotropes   to increase the mortality in severe heart failure .

The article in the current issue of circulation  shows  no mercy to CRT  in advanced CHF

http://circ.ahajournals.org/cgi/content/abstract/CIRCULATIONAHA.110.956011v1

So what  is  the answer to the ailing CRT industry ?

Go and catch class 1 and class 2 CHF population* .You will get plenty  , of course  it got ratified by MADIT -CRT trial .

* It is attractively called prevention of cardiac failure

For todays cardiologists traveling in time machine  may be made as   an  essential assignment . It seems  there is more to learn from history than the core medical science.

How  the knowledge evolved  ? . How  our ancestors toiled  ?  Where  are  the good old  medical   inspirations  ?

How  can we enjoy the fruits of success without knowing the  tree of it’s  origin ?

What you are going to leave for  the future man kind  ?

Learn how a  dream heart team led by Christian Barnard  created history in the year  1967 in a remote southern hemisphere  town ( To be precise Cape town ) , South africa .Click the link or over the image .Courtesey of Life magazine

Groote schuur hospital where Christian Barnard made history

Thanks  to the Life magazine  for providing these stunning pictures to the present generation

 

Christian Barnard and team after the historic  surgery .Groote schuur hospital .Cape town

 

Let us  salute  the men of  past  .We shall  take an oath   to  strive harder and  harder   and the least  , trivial achievements are not  glorified . .