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                                This is a  hemodynamic concept paper by Libanoff in 1968 published in circulation.This paper elegantly proved that  the rate of fall of pressure across the mitral valve will predict the mitral valve orifice.     This key paper formed the foundation on which  Liv hatle developed the echocardiographic pressure half time .This pressure half time derived mitral orifice area ( 220/PHT) is key parameter world over for assessing  severity of mitral stenosis non invasively .

Click on the link get this article .This article is available free fulltext from circualtion web site

pressure-half-time

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