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Great people  do not boast  . While there are thousands of hyped up publications in cardiology ,

This one form Qatar excels , which  I  stumbled upon recently  contains very useful information about wide ranging issues in cardiology .

Let us congratulate the   Hamad medical corporation for  their unique  academic vision  .

http://www.hmc.org.qa/hmc/heartviews/ARCHIVES/ARCHIVES.HTM

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That was a slightly  modified title of an article published by the renowned Nephrologist from India Dr.M.K.Mani

Who is also involved in the fight against live kidney bazaar  in India.

In this article he shares  his experience  ,  how   desperately he is  trying to correct a major conflict in physician laboratory nexus in India . It is has been an  elusive search for  the past 15 years.

And  the article  seems to the conclude  , there is no other option   , we (And our patients )  have to live with it .

But , what we need to realize is  we have our own  watch dogs lie within our mind , and it need to bark every time a thief is seen .

Let us awake our self for the benefit of our patient kind .

By the way , how many  among us know such an important journal is published from India !

http://www.issuesinmedicalethics.org/044ed105.html

Further reading

No doubt ,  such kick backs and gifts and ads make medical care artificially high and unaffordable.

The pathetic stories of how modern medical care create new breed of  poverty.

the poor can not get even the basic  treatment because they are poor  , while  the rich get costly and  inappropriate  some times dangerous treatment and become poor .

Link to The WHO article that exposes the Issue

I know there is  a book written by Dr M.K Mani ,  Yamarj’s Brother

I have not read it .I wish i get it soon .That Iam sure will enlighten us

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In any field  , errors and mistakes  transform into   experience in retrospect. (Of course only  if we  realize  our mistakes !) . Many would argue prevention of such errors is the  only way to move  forward in science  , but ,the opposite could also be true.

In Medicine ,

  • Most errors are mild ,
  • Some errors  can   be fatal but it helps us prevent further fatalities.
  • Some errors create history  and  re-define the science.

That’s   what  happened on 1958 , to be precise on  October  3oth , 1958  in a lonely laboratory of Henry  Ford hospital/Cleveland clinic *

*A correction -This  invention actually happened in Cleveland.  ( Sones learnt  all his techniques in Henry ford)

When  Sones along  with his assistant were trying  to do an  Aortogram in a patient with RHD,  the entire dye meant for aorta went straight  into  the right coronary artery.When every one was stunned ,the  patient happily  survived the injection  with a few skipped beats.

The man behind  this horrendous medical mistake was   Mr . Sones . He   was guilty for many days ,  spent many sleepless nights  ( In spite of  the patient surviving  the episode ). In fact , he was much amused  about the patient’s  survival . At that point of time,  even a spill over of dye into coronary artery was considered forbidden.  He pondered over the incident for months  .

Had  two queries  lingering in his mind .

  1. How the  right coronary artery  was able to withstand the 40cc dye  injected with  force .
  2. If 40 m l was tolerated ,  well what about routinely injecting  3-5 ml for visualizing the coronary  tree   by intentionally  seeking the coronary ostium .

That was the moment , the concept of diagnostic coronary  angiogram  was born . He published his observation as an  abstract in Circulation journal. Later he did many experiments  with video  engineering at Kodak labs , X  ray  technology to improve the cine imaging .By 1964 , he devised a perfect protocol  for doing  selective coronary angiogram. Then along with Rene Favaloro he pioneered CABG surgery in USA.

Final message

Cardiac  catheterisation was invented by  Forssman , Cournand , and Richards ,(Nobel prize 1956 ). It was  Sones who took it into the coronary arteries  and thus it was  made possible  for a whole new specialty  of coronary  diagnostics  and therapeutic PCI  which was  conceptualized by another extraordinary human life called   Gruentzig. Sones along with Gruentzig definitely deserve a Nobel in medicine which i think will happen soon ! They lived a great life constantly thinking, innovating  putting  patients interest in the fore front .

Mean while , I argue our youngsters  to  portray  the images of  these giants in  every   cath lab they  work   .You may get their blessings from heaven  , provided you do your interventions with integrity and honesty without any conflict of interest in the patient care.

Do not cry foul when some genuine errors happen in cath lab.Few among us (like Sones ) may innovate those mistakes into glory !

Reference

http://en.wikipedia.org/wiki/F._Mason_Sones#cite_note-3

http://www.wired.com/thisdayintech/2009/10/1030first-coronary-angiogram/

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This one is from Cleveland clinic in their CCJM 2009.  It answers all those tricky questions when we plan   anti – coagulation in  pregnant women .

  • Should heparin substitution/bridge   always necessary  during  pregnancy  ?
  • When is warfarin safe  pregnancy ?
  • Simple  cessation of warfarin around  the time of labor and resuming  it after delivery  (Without heparin  substitution  )  Is it an option ?
  • How safe is LMWH in pregnancy ?

 

The ultimate reference article 
on peri-operative anticoagulation

 

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A simplified animation strictly  meant  for understanding the concept

Link to the review article on the topic

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No one would have believed a century ago when electricity was first dosvovered  for the mankind by Benjamin Franklin  with glorious  purpose , would now  be used as a drug for treating  life threatening heart ailments  !

Yes , electricity is a drug by definition.

It is administered percutaneously  by focusing  a beam  of current into the heart.

  • There is a dose , shape , energy  and direction for this drug.
  • Paddle size determine the energy.
  • Paddle location determine the direction of  current vector.
  • Dose is selected by the  physician.

Mechanism of DC shock / Defibrillation *

When  heart suddenly behaves abnormally  and start generating its own electricity and sends it through abnormal channels other than its natural paths ,  it becomes a dangerous arrhythmia .This propagation of wave front can occur in multiple directions  in a chaotic manner , resulting in VT/VF and imminent death.

Like an air to air missile ,this  abnormal wave front  can  be tackled only by an another electrical  wave front . Nothing else will work.

* The difference between DC shock  and defibrillation is only technical. If one gives a  synchronised shock  ( with qrs complex ) it becomes  DC shock .If not ,  it is defibrillation

The success of defibrillation depends on many factors .

The following are most important.

  • The critical myocardial mass must be depolarized by the current delivered.Sufficient  amount  of sodium channels /less  of calcium  currents  need be activated for this to happen .(JACC 2008)
  • The direction  and the angle  of current entry with reference to  advancing  end of abnormal wave front. is also  important .
  • Distance between the paddles.(Antero posterior paddles more effective than Apex /Sternal pads )
  • Energy level (seems to be less important ! )

Two shock forms are used

  • Monophasic shocks
  • Biphasic shocks

A biphasic DC shock has  replaced the traditional mono phasic  sine wave  shocks in most machines.

What is  the  fundamental difference between the two  ?

  • In bi phasic  shocks , the current traverses the myocardium twice .
  • So, it has a second chance to interrupt the critical tachycardia  circuit , if the first one fails. In other words, biphasic shocks are  technically equivalent  to  “two  sequential low energy shocks”  delivered in opposite polarity . This change in direction happens in micro seconds .
  • The shape of biphasic DC current  wave form can be a truncated  sine wave or square wave .The maximum  energy of DC shock in biphasic mode  is  200 joules (In Monophasic it is  360joules) . All AEDs, ICDs, now use bi phasic shocks to conserve energy .

Final message

A biphasic shock waveform has a proven advantage . It has  greater efficacy ( because it traverses the heart twice ) , requires fewer shocks  with low  delivered energy and hence  less myocardial  and  dermal injury.

References

Even though there is general  acceptance of superiority of bi phasic  shocks ,  it is still considered by some ,  that there is no great difference in the  overall outcome .

http://content.onlinejacc.org/cgi/reprint/52/10/828.pdf?ijkey=5a8f50ff2542182c857d4f3fe553aef8df6e3fd3

http://circ.ahajournals.org/cgi/content/full/94/10/2507

Bi phasic shocks in atrial fibrillation

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1768486/

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It is often said medical   professionals lack engineering sense and vice versa. The filed of bio medical  engineering is is not  a new one . It is  there for over 50 years .The gap is narrowing very fast.

We are in the era of developing hybrid imaging , where a PET and CT come together. Raman spectroscopy is sending live  images of tissue histology from the coronary arteries .

A  journal exclusively catering to the cardiovascular enginnering is new development . Let us thank to the unique initiative from Purdue university .

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Blood pressure  measurement ,   probably  is the commonest investigation done  in our patients  in  the entire field of medicine . It is such a common thing ,  both physicians  and patients  fail to perceive  it as  an investigation . (It indeed is !)

Even though BP is  considered as a  clinical sign , measuring it requires a device called sphygmomanometer  . The BP apparatus has to be properly calibrated  with the mercury  , the tubing, the bladder  , inflation balloon  etc   need to be perfect.

The following fallacies are noted in the measurement of  blood pressure . Some of them are rampant* !

Patient

  • Posture of recording
  • Anxiety -White coat /Gender

Device

  • Cuff width/Length
  • Arm circumference

Ocular errors

It is surprising , such an important tool has a scale of 2mm markings which is prone for parallax errors of light with  mercury column undulating .

Physician factors*

  • Hasty cuff syndrome , Rapid deflation .
  • Absent minded recording – Failure to note phase 4 to phase 5  due to inattention
  • Failure to hear phase 4 muffling  (Aging  medico  -Auditory insufficiency !)

It is  not at all  surprising  to note,   two BP readings rarely match ,  even if it is recorded by the same person with  same machine at the same time !

There are many  articles that describe in detail  ,  how to record blood pressure properly. But this article from  a relatively unknown  journal   from Purdue university  ,  tells  us  most   scientifically  , what  has been taken for granted  by the medical  community for so long  .

Loose cuff  hypertension (Link to the journal of  Cardiovascular engineering )

How much  stiffness  is to be applied in  the arm for optimal pressure recording ?

What is the incidence of hypertension due to  loose cuff  ?

Final message

The BP apparatus ,  though appears  as  an   innocuous   machine ,   the readings  that emerge  from it  determines ,  how millions of our fellow human beings are going to be labeled  ! ( High pressured  humans ,  slaves to  anti hypertensive  drug marketeers    for  rest of their  life ) .

So , realise  how important  it is , to measure  the blood pressure properly    !  Never be casual . . . with  this  machine .

Experience has taught us ,  while  it is very easy to name an  individual  wrongly as hypertensive  , it  often needs  Herculean  efforts  to remove this medical tag from their neck . The reasonings  are  many .( Academic , non academic and patient factors included )

Finally , in this funny planet  it is  a personal observation ( Or is it  an imagination ?)    some  men and women   tend to  enjoy  ,   being  referred to  as  high pressured !   Loose cuff  or tight cuff   ,  it simply do not bother them  !

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Cardiology as  a specialty  has grown faster than any other field in medicine.  From  the days of  Da -vinci and  William Harvey  ,  the  urge to understand the  intricacies of  anatomy and physiology of this organ that sustain the rhythm of life ,   life was tremendous .

Heart was a gift of life  by God to the man kind

  • Few men dreamed about it.
  • Few were simply fascinated by it .
  • Some   exploited it in the name of science .
  • Only   few  spent the entire life  for it   ,  explored it  passionately . . . truly and genuinely .

One such person , we should all celebrate is Noble  O  Fowler  From Cincinnati USA. This unassuming  ,(In contrast to  some of the current hyped up  achievers !) has kindled thirst in the subject to many  youngsters .

His remarkable achievement included

  • The  pioneering thoughts about pre-infarction angina (Now labeled as unstable angina)
  • Pericardial physiology and pathology
  • A overall approach to cardiac patient with shrewed physiological and pathological sense.

His book cardiac diagnosis was a exclusively authored by him is still considered as unique as his life.

Some how this book never got published beyond the 1980 s.

I personally  dedicate this  little service to cardiology literature to the legacy of Noble O Fowler.

A tribute by his Collegue Robert J Adokph

 

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