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A young women  with Rheumatic heart disease .

 

LA aneurysm

Giant left atrium in rheumatic MS . http://www.drsvenkatesan.com

Mitral regurgitation is significant .www.drsvenkatesan.com

 

When do you call  a left atrium as   giant  ?  When it is referred to as  Aneurysmal dilatation ?

It is all semantics. Whenever LA becomes more than 6 cm ,  at least in two diameters  many prefer to call it giant .

In India , 6 cm LA is such a common finding , we have kept a  cut off at an  arbitrary 9 cm .

What factors determine a LA to dilate like a balloon ?

The exact mechanism is not known.It could be  the  intrinsic weakness of LA wall ,  as very few with RHD develop this. Many LAs resists dilatation even in the midst of extreme LA pressure. But , it is a well-known fact , mitral regurgitation provokes greater LA dilatation than MS alone .This implies volumetrics  play a major role than  pressure dynamics  in determining LA size. Acuteness of hemodynamic insult is  inversely proportional to LA size.

By the way, what is the purpose of  recognizing  the LA as Aneurysmal ?

  • In plain X -ray chest , LA may  form the right heart border  over shooting the RA.
  • When LA becomes huge  , there is a  chance for mechanical complications  like dysphagia, phrenic nerve , bronchial compression etc .
  • Giant LA invariably increases the chance of LA clot.

Electro-physiological Issues

  • Atrial fibrillation , a usual accompaniment of giant LA ,  is often refractory . There is no  purpose  to convert to sinus rhythm . In fact ,  one should not attempt this. There was a time when surgical incisions  ,corridors , mazes were quiet popular.Now it is believed all these are adding further injury to the ill-fated LA .Electro-physiologists should be restrained . Pulmonary vein ablation should never be attempted in such cases as the focus of AF is elsewhere .

Implication in cath lab

During PTMC LA size can be an issue  as the plane of IAS is distorted and make things difficult for septal puncture . Further the balloon , guidewire  may often slip  back into RA .

Implication for the surgeon.

For the surgeon the implication could be more. As a cardiologist I can’t comment about that .One thing we have observed is when LA becomes huge , the size of mitral annulus is too fictitious and funnily enough we have recorded up to 6 cm of mitral annulus . No valve is available for this size . We learnt from the surgeons ,   large LA  rarely pose a  problem as they suture the much  smaller valve in a larger annulus .(Which  makes the task  that easier )

Does the LA size regress after surgery ?

In many  it does regress  , in as many it doesn’t. We have seen giant LAs continuing to trouble the patient even after a successful mitral valve replacement.

A classical echo of  a common AV canal .

 

Note  the free floating common AV leaflet

An ASD

A  VSD

With all chambers interconnected it is a free for all circulation . The blood  seems to get mixed at the level of common AV orifice . Even though one expects severe cyanosis in common AV canal , the intensity of which is primarily determined

Common AV canal with free for all shunting . http://www.drsvenkatesan.com

 

the net blood flow to lungs which is dictated by  the pulmonary vascular resistance or the RVOT obstruction. This patient had no RVOT obstruction   but had  severe  pulmonary arterial hypertension.  In spite of raised PVR ,  some amount of volume over load of lungs  occur.

How to assess the  operability ?

Ever since coronary stents were introduced   metal market is having a  good time within human coronary arteries.The search  for the the elusive , ideal metal is still on   . . .  Nickel , stainless steel  , platinum  etc .

Some body thought , why not gold ?

For long ,  gold is known to be a good bio -compatible metal .

Two Gold stents were tried  .

  • Inflow dynamics  – AG Germany
  • Boston scientific –  NIR stent

Surprisingly , both showed   increased reactivity  with  coronary endothlium . The verdict  was  clear . Gold coated stent  was not good enough.

http://circ.ahajournals.org/cgi/content/abstract/101/21/2478?ijkey=f03f3c40dc4c5b2673d783f91c19f5ea685ed514&keytype2=tf_ipsecsha

Gold allergy

http://onlinelibrary.wiley.com/doi/10.1111/j.0105-1873.2005.00522.x/abstract

Final message

With the advent of DES ,  gold coating of stents lost it’s popularity  .Unless  new innovations happen in gold metallurgy , the  future looks bleak  for this precious metal  , at-least  in  the human coronary arteries.

Radiation injury to coronary artery  is rarely given a thought , in spite of   prolonged fluro-scopic time  during  many complex angioplasties.While the cardiologists are fully protected the patient’s heart takes on the brunt of the attack.

What happens to the coronary endothelium -metal interface when X -rays pass through it ?

It is well known the radiation delivered to a tissue is many times  amplified if a metal interface is present. Further , the metals can produce heat on exposure to radiation . This absorption and heat varies with different metals .

The radiation injury to coronary endothelium  could be  significantly higher with DES , as the polymer in it absorbs more radiation than the bare metal stent. This could be responsible for late complications of DES.

The above  concept (unproven though !) is  proposed  by  http://circ.ahajournals.org/cgi/content/full/104/5/e23 .In this study Gold coated coronary stents were found to be less safe than conventional stent

It may take many years to know the truths  about  radiation injury caused by  of coronary stents  .

But always remember , unproven concepts are  not synonymous with wrong concepts !

A middle aged female came with palpitation and breathlessness for two months duration  to  our OPD.

Clinically a non ejection click was present .She was referred with a diagnosis of MVPS  to the echo lab

Her echocardiogram created a  real buzz in the lab .

What is the diagnosis ?

The diagnosis is  hidden somewhere in the frame.

How common is this entity ?

A Color flow imaging is available  will be posted  if requested .

Internet has revolutionsed the way we learn . Now,  you can watch experts  perfoming  complex cardiac surgries sitting at any where in the globe !

The credit not only goes to the broad-band internet , but also the greatness of   European association of cardiothoracic  surgery  which has made it available free of cost .

A must visit website for all those  physicians and surgeons ,  concerned with  cardiac care of our population .

LBBB is a common ECG abnormality .The ECG is so classical , no one ever misses the diagnosis. But , what we miss  often is the significance of it .

What is the cause of LBBB in a given patient is much more important than the LBBB itself !

Though the commonest cause of LBBB is a benign one (Pure electrical defect without any valvular , myocardial or ischemic heart disease ) , it is prudent to rule out organic LBBB   . The term  organic  here refers to structural or ischemic etiology .

LBBB  & STEMI

To diagnose STEMI in LBBB we have the much famed  Sgarbosa criteria .It is a too popular to forget in spite of  it’s limited utility . Applying it in an emergency is not easy exercise . Clinical prediction , cardiac enzymes are  safe and could be more accurate. Thanks to  ACC guidelines  , it has simplified our task .You  are encouraged to thrombolyse all cases of  new  onset LBBB* if clinical picture is strongly  suggestive of ACS.(*The term  “presumably new” onset LBBB  was included  , implying  it is better to err on the safe side )


LBBB & NSTEMI

No one knows how to recognise NSTEMI in LBBB. Logic would say, primary ST depression might occur. How sensitive it is , and which  lead to look for is not known.

LBBB in DCM

Here is an  ECG of a patient who came to our OPD  absolutely asymptomatic for a routine review . He is been diagnosed as a case of  dilated  cardiomyopathy with 30% EF and  no evidence of  ongoing  ischemia.If the history is not known he would have been  diagnosed as a ACS.

To diagnose cardiomyopathy in LBBB we have no specific criteria. But  we have found the following useful

  • Extreme left axis deviation > Minus 45-60 degrees/AVR positivity
  • Low voltage QRS , especially in limb leads
  • ST depression is more flatish  than  the typical  secondary ST/T changes of LBBB
  • QRS notching or slurring either in the r wave or s wave.
  • Atrial abnormalites as evidence by wide P waves.
  • Associated VPDs

Further inputs are welcome to differentiate organic from benign LBBB

Counter point : When we have  facility to do  bedside  echo , why should we  scratch our heads ?

Do not waste time , do a spot echo  . . .

Echo can be very useful in ruling out cardiomyopathies and old MI.But  remember , echocardiography is  unpredictable to detect acute septal MI in the presence of LBBB  , as  paradoxical motion of IVS tend to mask the  ischemic wall motion defect .A simple clue is normal systolic wall thickening will be observed in benign LBBB ,  in spite of  paradoxical  motion .This thickening appears as  post systolic beaking  that  face posteriorly . In STEMI and LBBB thinning or absence of thickening is expected.

MASS 2  study , the 10 year follow-up results are just out in circulation   september 2010 .

It is a rare study , where “one  to one vs  one” was compared  ie  the effect of  medical,  CABG , and  PCI    in chronic CAD .This was done in a single centre in Brazil,  between 1995 -2000 . It was  followed  up till 2010. Interestingly ,  such a study  may not be possible in the future ,   as  many of us  have  prematurely  glorified  the PCI and CABG over medical therapy . Recruiting  patients   for medical therapy alone is becoming a  difficult  job even in  developing countries.  Even if we recruit , huge cross over is likely  to PCI, CABG for all fancy reasons.

So , in MASS 2 we have a rare treasure on hand . . . Let us give three cheers to those  Brazilians  who did this study ,  and  shall carefully analyse and  interpret the results.

Highlights ( According to my  interpretation)

  • A total of about  600 patients with 200 in each group.
  • The overall death at 10 years  is not greatly different . (Around 25 % )
  • But ,cardiac deaths were distinctly higher by few percentages in pure medical  arm
  • Need for crossover  from medical to surgery and PCI to surgery was significant.

CABG tended  to prevent future MI in this study . This  could be  most significant observation from  this study ,( A revelation in fact ! ).It is against the popular  belief  created by CASS  legacy.

What are  the observed difference  between MASS 2 –  5 year results , which was published in 2004 ,  and  the 10 year follow-up , as  on  2010 ?

At the end of 5 years in 2004 , the differences  among the three groups were not obvious.The benefits of CABG mainly appeared after the 5th year and at 10 years it was significant.

Shortcoming of MASS 2

  • It is a single centre study .Numbers were less (600) .
  • It need to be emphasised    CABG was done  with  pump in all patients  . So the currently prevalent off  pump CABG  may not be really  comparable with reference to outcome.
  • Only   bare metal stents were used in PCI .(If only DES was used  . . . Considering the host of issues for and against DES , it will  be a  wild guess to judge it’s implication .  It could  have  tilted , either in favor or against  the  PCI  limb .)
  • In medical  limb ,  statins were not used in all.  Further , the dose of statins were not aggressive.This makes medical therapy appear less effective.

Intriguing  thoughts

When we say medical   therapy is  being  compared with PCI and surgery , we are actually comparing ,

Medical therapy  alone

Medical  therapy+ PCI

Medical  therapy + CABG .

Every patient  in all three  groups  receive  statin , antiplatelet and beta blocking drugs and so on.  Even though  statistics  would  vouch for  additional  benefit ,  over and above medical therapy  , in a given CABG  individual ,  how much  of the  the  accrued benefit  is contributed by co- administering   medical therapy  .It  is beyond   reasoning even  with all  gimmicks of statistics.

To exactly quantify  the individual benefits and efficiency  of  PCI ,  CABG  and medical therapy  two more  study limbs are necessary .

  • PCI without drugs.
  • CABG without drugs.

Such a study is possible only in a virtual world ! .  Decision  making  in favor of CABG ,  especially   in chronic stable angina ,  will continue , to be  difficult in the absence of refractory angina .This is due to  the modest benefit of CABG ,   that is  expected,  at an additional risk , cost and  expertise.

Please remember, a person can survive  , only  with medical  therapy for > 10 years  but no one can ever live with PCI or CABG  for that period of time without  adjunct drugs  . Guess  which modality   is  going to win the race  against CAD  in the long run  ?

Final message

If  any one  asks  for  conclusion of MASS 2  study ,  don’t ever say  “CABG is superior to  medical therapy” . Please emphasize , “CABG + medical therapy could   be , marginally superior to medical  therapy alone in some of the patients with chronic stable angina. (Each word  in the above statement is  important !) .

So . . . MASS 2 : Is it a  shot in the arm or shot  in the head for CABG ,  we do not know !

http://circ.ahajournals.org/cgi/content/abstract/122/10/949

http://circ.ahajournals.org/cgi/content/full/122/10/949 .This study was done by Zerbini foundation Brazil

Brazil is not only known  for the glorious sport of football . In the medical field  they are among the leaders in cardiac surgery .When cardiac surgery was at it’s infancy even in USA and Europe , one man showed the ultimate determination to take cardiac  surgery to the virtually unexplored region of south America in the 1940s and 1950. He is the pioneer of cardiac surgery for the entire continent.

Picture courtesy  . Annals of thoracic surgery  .

He is the founder of INCOR .  Now , Zerbini foundation is   carrying the legacy of this  man. He has  trained  so many cardiac surgeons that makes Brazil one of  the hot  destination for hi tech cardiac surgery .Recently the foundation sponsored the landmark study called  MASS 2 which compared medical, survival and interventional  forms of treatment.

This journal ,  dedicated to  cardiovascular  surgery from Brazil is doing a great job. Most of the articles are free.The Brazilian  progress   in cardiology and cardiac surgery  is  a   “No  mean” achievement.

Learn for yourself how the country ,  which many  think  is not yet  developed is doing pioneering  research and  perform  state of the art cardiac surgeries. Often their  concepts and techniques are so unique  and innovative , evoke criticism in other quarters.

It is ironical , some of  the mediocre journals  from affluent countries are making  waves , this one  deserves much better recognition !