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A must read for all clinical cardiologists  and fellows  .   A comprehensive review on pericardial diseases.

It also  highlights a new diagnostic parameter in cath lab to differentiate constrictive pericarditis  from  restrictive cardiomyopathy .The area subtended by RV pressure curve and LV pressure curve moves discordantly in constrictive  pericarditis   while it moves concordantly     in restrictive  cardiomyopathy

Source : Mayo Clin Proc. 2010;85(6):572-593

 

Coronary collateral circulation is probably the most poorly understood circulation than any other.This  is ignorance at it’s best ,  in spite of the life saving potential  of this circulation. A popular  (mis )perception is  coronary collaterals  can support only  resting blood flow and it would  struggle  to compensate at times of exertion. This is based on few case studies and not based on large , authentic scientific data.

Does this reasoning mean  , coronary  collaterals   can never / ever be complete  ?

If we believe so   . . .we are grossly underestimating the power of  nature .(In fact , mankind  was humiliated by the nature  time and again !)

Lessons  from  a unique patient we have  encountered.

Here is an example of total LAD/LCX  occlusion with good collateral  from  RCA. He was having  stable  angina on medical  management . This patient  was not only  asymptomatic and was also negative for exercise  stress test at moderate work load .

 

 

 

 

 

 

 

 

 

 

 

There was an  intense debate about the management  when this angiogram was presented in the cath meeting .


 

 

 

 

 

 

 

 

 

 

  • Most of the cardiologists believed so !  But they had no answers why his stress test was negative.
  • The other argument for CABG was one can not allow a patient with a functionally single coronary  artery (RCA) However good is the collateral circulation.This at least  has some logic. not the first one !
  • One more suggestion was to quantitate  and map the real extent of ischemia by PET scanning and then decide about revascularisation.
  • One critical opinion was , since he was doing well with medical management what was the need to do coronary  angiogram at all ?

Any answers  . . .

He  ultimately went on to receive CABG (By popular opinion ) , but the point here is the collaterals were  good enough to support exertion.We have  documented quiet a few similar patients with collateral circulation supporting exercise.

What  happened to the collaterals  and (of course ) the patient after surgery ?

I will post you the  curious story soon   . . .

Final message

Coronary  collateral circulation , if well developed  can provide hemo-dynamically useful support even at times of exertion *

* The existing literature  is  biased against this concept. It generalizes all grades of collaterals into a single   entity. It is better  if we  spend more time to understand the nuances of coronary collateral circulation .

This is the  message from our observation. Do not ever believe whatever is published as facts in scientific literature. Observe, analyse , create your own inference ,  and concepts. Mainstream cardiologists would brand it unscientific  , Simply ignore it . Many times it is rewarding  to our patients.

It is often said optimism is key to success . From the patient’s and physician’s  perspective   it is the willpower that has saved many lives. Positive minded patients  do not die without fighting. We  know self belief can do wonders in medical  care  !

If  self  belief is  the ultimate healer ,   trusting the   doctor  and  the hospital  are  equally important  . Patients believe in  doctors and doctors believe in science . Science is not sacred .It is man-made   .Those men  who create  science  need not be  holy  either !

Can  we  trust modern medicine in the current form  ?

I am afraid the answer is  too tilted towards  . . . “No”   I am not a pessimist  in the strict sense  . However ,   the future   looks bleak  in most places  ! unless some strong remedial measures are under taken.

Statistics   suggest , patients  are  rapidly losing   the belief   in their physicians   ,  considering the track record of our  health care management in recent  times . Global trends in the last 5 decades indicate the health care delivery system has gradually  been  hijacked from the Govt to the private hands.

It is  quiet a shocking  revelation ,   the private  sector  health care  has done  more damage  than  the state   driven health care . How  foolish   our expectation  can  be !   For fulfilling the millennium  goal ( Health for all )  most  countries  have  handed  over the  baton  to the  greedy corporates .

How on earth , one can expect  the   private / corporate  sector  to provide  equitable health   for all  . It  would be wealth for all  those involved in  this flawed medical care  system  at the cost of  poor !

Read this book  . . .To understand the nuances of how our health care industry is bulldozing  , like an army tank into the population  and  most of us  is a victim or a partner to this .

Click here  for  the  Book review

From The Hindu January 2011

Final message

Entry of capitalism into health sector is probably the worst  infliction   man kind  has suffered , than all those deadly viruses and bacteria   over a last few centuries !

Medical science is a phenomenal  gift  created , nurtured and grown by the sixth sense of our ancestors .Their only aim was to provide relief to the sufferings.  Now their dreams,  vision and goals lie  shattered .

No hospital  has a  specialty called  “humane care”  , while  many  have  a separate  department   to  do a  neuro  metabolic imaging    for a  depressed  man with Alzheimer  disease   in his nineties   and  a  Bio – Robot  driven    fuzzy logic  lab   to  predict cardiac  events  in a soon to die rich man . Absolute waste of resources !

There is  no doubt , we have become a  sort of  salves to  science  . . . (Irrational science to be precise ! ) It is a man-made monster.  Even a most conservative person  (including the author )  could    be causing  some damage as we  are forced to follow  the unruly scientific publications .  Probably  . . .yes . . . we can’t eliminate  it   but   identify  futility of modern science try to get  rid of it . !

A related article

Those were the days   . . .  When doctors practiced medicine  . . .and much more  . . .

A  wonderful  piece of writing   by Dr Susikaran  Thangasamy from the open pages of  India’s national newspaper

‘The Hindu” http://www.thehindu.com/opinion/open-page/article1137935.ece

What is the remedy ?

First of all , every one should answer this question to their conscience

What ails  our health care  system  today ?

Do not be part of it . . .  solutions  will come automatically !

Left main divides into two. Some times into three . Very rarely into 4

Look  at this angiogram ,  This looks  like  a quadrification, if not quadrification equivalent

Clinical implication

A 4 way division invariably means the OM and diagonal or going to be diminutive.These people are expected to have favorable coronary hemodynamics during ACS , and  left main lesions are  less likely  to  occur

Reference

This article is from Singapore medical Journal

Life cycle of PTCA : Let us hope it do not become extinct !

Does PTCA  , a great Innovation for mankind,  is facing a threat of  extinction ?

It seems so . . . the stents  are losing its shine  in most situations. A simple evidence  . . . for that . . . can  be found in answering the following question

What drives the extensive research in biodegradable stents now ?

The simple answer is , we are fed up with the metals inside the coronary  artery. We want to get rid of it !

Too much of knowledge , often blunts our senses . Our track record clearly  reveals this fact. We needed a major study INTERHEART to tell the world   that  ,exercise is good and tobacco is bad for heart  !  Now ,we forgot a  simplest solution for  getting rid of  metal inside the coronary artery ,  which  is  “not to implant  the stent”  at all ! (Instead we do billion dollar research for making  bio – absorbable stents ,  which in the first place may not be required in the majority !

Read the related article . Does POBA has a role now ? in my site

The only situation  , where PCI   may  withstand the test of time could be in ACS (Both in STEMI and high risk NSTEMI !) PCI is cosmetic in most of the chronic coronary syndromes .

Final message

Our fight against human atherosclerosis will have to be , by medical means .PCI at best will  provide  a supportive role in selected patient group. It requires lots of common sense  and   scientific ignorance to achieve this.   Risk reduction ,  prevention , optimal   medical therapy  will have to play a dominant role in the next few decades .  This is something similar to the environmental issues we face in protecting our planet .No amount of green industry  will protect  the earth . It requires better social and  behavioral  ethics  from  mankind   and their  rulers !

God creates life  with  infinite variation .  The  heart gets  bulk of its blood supply from the left coronary  artery , which divides into two  after a short course.  Bifurcation is the rule . Left main becomes  left circumflex and LAD  in about in 85-90 %.

Note the left main divides into 3 equal caliber vessels.very lucky to have such a branching pattern !Distal left main is unloaded by three large ostia . This makes stasis of blood in left main very unlikely . LAO caudal view

 

 

Note : The OMs are small in these people. RAO caudal view

Few men and women are blessed with three branches from LCA . The anatomical and physiological importance of this  branching pattern  is not well analysed in the literature .There  could be  few advantages  of having a trifurcation instead of  bifurcation .

  • Left main  impedence is less in trifurcation . This is due to the fact ,  left main empties into three distinct ostia rather than two.The combined  cross sectional area of these three ostia  confers a hydrodyamic advantage.
  • The importance of  any proximal LAD lesion in these patients , is negated  by  33 % as two other vessels are there to take care the  rest of the heart.
  • A large Ramus usually  supplies a vast area in the angle between LAD and LCX.  This   has a potential  to protect against ventricular  fibrillation during acute occlusion of LAD  by providing  electrical stability .

Disadvantage of trifurcation !

  • It is also a fact , people with a large Ramus may have a trade off by having a diminutive diagonal or OM .
  • A trifurcation with a small calibered  ramus  can often  be a disadvantage , as it is prone for atherosclerosis  since it  restricts  left main flow  by  venturi effect . (The first rule of atherosclerosis states its  prone at branching points)

* A related blog  elsewhere in my site . The explanations  offered above are based on personal observation .

https://drsvenkatesan.wordpress.com/2008/12/16/what-is-clinical-significance-of-ramus-intermedius-coronary-artery/

Few web sites provide   free  cardiology  service.  This one from cardiomath beats  all  ! It makes the job easier for all those cardiologists who spend  lots of time in echo lab . It provides  simple  online tool  for all common calculations in clinical echocardiography

Here is  the link to the website of cardiomath

With  due  Courtesy   to

Author: Dr. Chi-Ming Chow  Developer: Edward Brawer  Illustrator: Ellen Ho
Sponsored by  Canadian society of echocardiography

Nothing in this world is black and white. In fact,  most events are in between . The irony is , our brain  always wants to view  things in two distinct entities !

  • Success or failure
  • Beautiful or ugly
  • Good or bad
  • Win or lose,
  • Rich and poor etc . . . etc

So it is no  surprise !  cardiologists  also travel in the same boat !

They classified  the events after thrombolysis   into two dogmatic categories . Successful  thrombolysis or failed thrombolysis   . . .  as if no other event  can occur in between .

Traditionally 50% regression of ST segment is called successful .   What  about 30%  and 40 % ST regression ?

Further , there is an important caveat  in the timing,  as we  traditionally assess ,  90 minutes of thrombolysis .

Consider the following  situation  :

  1. Thrombolysis  is failed at 90 minutes, but  succeeds  at 120/180  minutes ?
  2. Is 50 % ST regression at 180 minutes is as bad  or as good as 25 % regression at 90 minutes ?
  3. How to label a patient who  is extremely comfortable in spite of ECG criteria of failed thrombolysis ?(Surprisingly this situation is fairly common !)

So, without finding answers to some critical questions , we have defined the success  of thrombolysis with  half baked data .

This is exactly , is the reason we  are unable to do a  valid  study on failed thrombolysis, rescue PCI etc .  We know the results of rescue PCI  ,  always  been  contradictory to the general logic !

It is estimated a substantial number of  STEMI patients following   thrombolysis   fall into a category of partially successful thrombolysis implying partial restoration of blood flow and salvage. The correct definition for  successful thrombolysis and reperfusion should be at the myocardial mass level , and  not at the level of coronary artery.The ECG  is the best available indicator.

Implication for having a  poor definition  of  failed thrombolysis

It is not a rare sight to wheel  in , a patient to a cath lab  with label of failed thrombolysis dangling in his neck  who is clinically  stable  (Has a less than required 50%  ST regression , but a definite, favorable trend with a 30 % ST regression  at 90 minutes  )

How many cardiologists will be willing to abort a CAG/PCI  , as a repeat ECG just  before puncturing  in the  cath lab reveals    successful  thrombolysis ? (little  delayed though !)

If only we have better methods to risk stratify patients following thrombolysis , we can avoid

  • Huge costs incurred
  • Expected and unexpected hazards of doing an emergency  intervention in an adequately salvaged STEMI
  • Hundreds of cardiology man hours can be saved  for better purposes .

Final message

Classifying thrombolyis into  success  or  failure  is a  skewed  way of looking  at this important  issue .

It is an irony ,  cardiologists often  triage LV dysfunction , valve disease , cardiac failure  etc  into 4  grades (  minimal  , mild , moderate or severe  ) . It is  still a mystery ,  why thrombolysis  is never graded  like that ,  and it is always considered as  all or none phenomenon !

There is a substantial number of patients  with partially successful ( or shall we call partially failed !) thrombolyis  .This group must be given adequate attention or inattention  . There  is a urgent need for a through review of how we look at  the post thrombolysis status  . It is better to use the newer imaging modalities like PET/MRI more  liberally to identify  exact sub group  of failed thrombolysis who will benefit form revascularisation .

Is it not ,  boring to  see  normal coronary arteries every day  ! There need to be surprises  in cath lab to make our time lively  and keep our brain alert .  Have a look at this angiogram in  RAO caudal view.One of our junior cardiology fellows thought it was  a split left main artery .

How can an artery split . . .of course the image indeed looks like that !

It was indeed an absent left main.  Also called as separate origin of LAD and RCA.

Note : There can be three  types of absent  left main.

  • LAD and LCX from same ostia on the left coronary sinus*
  • LAD and LCX separate  ostia but both from same sinus**
  • LAD from left coronary sinus, LCX from right sided sinus (Probably the  common type )

* Some books mention about a left main of 0 -5mm .

** Very difficult to delineate and is rare

Zero  mm  left main is nothing but  single  ostial origin of both LAD and LCX. A very short left main , say 1 0r 2 mm will practically mimic an absent left main.

Here is the  the dynamic angio image. It is  surprising how a catheter in left sinus is able to visualise the LCX from right sinus so well !

Note the separate origin of LAD and LCX.The LCX was originating near the right sinus.It is intriguing to note even though they originate in different sinuses , the main stem of LAD and LCX wants to maintain a close parallel relation.

 

 

Advantages of having  absent left main .

  • It requires no great brains  ,  to predict  the above patient is  immune  to  develop  Left main  or true bifurcation disease
  • Sudden death is  presumed to be less common in this population.

Implications for interventional cardiologists

Guiding catheter selection and positioning could be difficult.

Manuals are not only for doctors . There are few heart  maintenance manuals for patients as well.

This one from Philadelphia ,  is worth reading and of-course  following  thereafter  !

 

Some books can be as effective as CABG or PCI .

This  one is definitely in that league  . . .