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A  72 year old man in  terminal heart failure with  three previous admissions in  last one year  comes with severe breathlessness . He was  exhausted with  rigorous  drug regimens  for refractory heart failure in the past few months. Since he  was always feeling better after an infusion of Dobutamine he demanded it . Doctors were very clear  , ” Repeated  Dobutamine infusion will  hasten  the LV dysfunction and longevity is  will shorten”

The family began to think . While they  wished  for him to   live longer , the sick man  insisted  on  early  relief from his  symptoms .

How often in medicine ,   there is a trade off  between  symptoms and survival ?

It is a more common situation than we believe , especially in many  chronic  disorders like terminal organ failure and malignancies. .  So we need a simple scale to  asses the quality of life and survival  outcome for our patient. The following table  could help us . I  learnt this from   the great teacher Valentine Fuster’s  lecture  which  I attended in New Delhi recently !

Final message

Let us  attempt to  make a patient’s  life ” feel  good “ ,  if  he is going to live shorter .  Let us avoid  prolonging  a  life ,  if the treatment is making him feel  bad  , when the  life  expected  is  short !

You are asked to see a patient with a pulse rate of 45 /mt .  Is it sinus bradycardia  or  complete heart block  ? 

Only one condition , . . .  you must conclude in the bed side !

  • Heart rate  may give a clue ( HR of  30-40 is common in CHB . Less common in sinus bradycardia.)
  • Pulse volume is large in both (More so in CHB )
  • JVP  shows occasional cannon waves hitting the neck  in CHB. Cannon wave can never occur in sinus rhythm
  • S 1 intensity may vary in CHB (As  Marching through  of  P waves  occur in CHB  ,  when it falls close to QRS  , it results in a  short PR interval  and a  loud S1   . Since marching through is a intermittent phenomenon S 1 intensity also varies.)
  • A short systolic murmur may be  heard intermittently due to   trivial MR/TR in CHB  ( Competitive AV valve movement )
  • A  simple bed side test  . Ask the patient  to exert for a minute -Sinus bradycardia raises  the HR with a fair regularity  to 80-90/mt  or so. CHB doesn’t  (Note :  CHB with  junctional rhythm can  sometimes increase the HR  significantly )
  • Finally response to Atropine   is prompt with sinus bradycardia.

Final message

Bed side skills in recognising cardiac arrhythmias are still relevant even in the current  era of carto and 3d electro anatomic mapping .

After all ,  the 19th century clinical wizard Wenke back recognised the second degree  AV  block at the bed side  well before  the ECG machine  was invented. He meticulously observed progressive prolongation of a-c interval and subsequent drop of c wave in the jugular  vein !

International Astronomical Union  in the year 2006  removed Pluto from the solar system for a simple reason ,  the so-called Pluto never revolved around  Sun , hence it ceased to be a planet of the solar system , it was more of an asteroid !

So, an astronomical fact engraved in our brains for so long  became a fairy tale. It is very hard  to erase  a  myth however solid the new evidence are against it.

The concept of HDL as good cholesterol has been etched deep in physician as well as our  patients.

Now comes the shocker from Lancet

How are we so sure ,  about these  Invisible spheres of  lipids that  move  around  our “Bio-system” in a presumed fashion .  .  .  even huge visible planets  fool us easily !

The Link to lancet study

It is  a wonderfully done study where  thousands of patients  who exhibited  genetically high HDL levels , never showed any advantage in terms of CAD prevention.  A stunning blow to a belief.

Incidentally ,  few years back  the failure of  drug Torcetrapib proved the same point  .  (The drug which elevates  HDL  proved useless in preventing CAD  ) but the  medical world failed to interpret it properly.

I am sure, still sections of physician  community would continue to believe HDL is great molecule for CAD protection !

Science is  often what we presume . . . but the fact usually turns out to be some thing  else !  but the journey towards truth  must continue !

                      When  a  million tonne  Pluto  suddenly disappear from Solar system . . . it is not a  big deal for  a  “miniscule medical myth”   to get shattered !

An  article , I stumbled upon recently  discusses why American health care is  in deep trouble. There is a huge variation in the health care costs across the country. The article goes on to reveal  ,   a  simple  Appendicectomy can  cost  anywhere between 7500   to 1,70000 $  in different hospitals in USA.  (In India it costs  1000 $  in  any  star hospital !)

The fundamental flaw is   treatment  being the same ,   it is delivered in such a  fashion ,  the cost incurred is  kept ridiculously high.

It is akin to comparing  a 10 dollar  lunch to a 1000 dollar feast , both  ultimately  fulfills a  purpose ,   relive the hunger effectively

while , the later can  damage the country’s economy  in a variety of ways !

https://www.massdevice.com/blogs/massdevice/anatomy-walletectomy

Car makers automate the industry with Robots to   reduce  the  human labor and  cost of a vehicle ,  while medical industry does the opposite   . . .  privileged few get their appendix removed with a help of metal hand  !

Final message

Modern medicine must  aim to improve the quality  of  care  with a   positive impact  at a reasonable cost . In the name of cutting edge technologies ,  it  should not raise  the medical bill in a meaningless  fashion .This is meager exploitation of  human suffering.

It is  hilarious to note  certain medical  Robots* are primarily  made to assist  surgeon  for which  no assistance is required at all !  (I heard a story about a  Robot  which responds  to voice command   and pass on a   knife  for cutting and a gauze for wiping ! What a great medical discovery !)

Disclaimer

*  Of course  Robots (Cyber knifes )   may have a role  in some rare surgeries which require high precision  cutting  especially in  Neuro  ,  Vascular ,  oncological  surgeries.

Acute rheumatic fever classically involves large   joints of lower or upper limbs  referred to as  fleeting migratory polyarthritis .But this pattern is  not  exclusive.  In fact   acute rheumatic  fever commonly  present with atypical features .The incidence can be up to 25 % in various series .The most surprising thing is ,  it can involve spinal as well as hip joints . Mono arthritis is also possible.

The only contention is , atypical features are  frequently  labelled by  some  as post streptococal reactive arthritis instead of rheumatic fever .

It is  pure  semantics at play . Whether you agree with the terminology or not  ,  never hesitate to diagnose rheumatic fever when the  joint involvement is  atypical . If  you ignore this  you are bound to  be guilty  for damaging few hearts  later.

What are the unusual joint involvement in acute rheumatic fever  ?

  • Small joints of the feet
  • Small joints of the hands
  • Cervical spine
  • Wrist
  • Elbow
  • Shoulder
  • Hip
  • Thoracic  spine
  • Calcaneus
  • Lumbar spine

The involvement of above joint can be up  to 25%

Here is an excellent paper from Brazil about the huge variation in the pattern of joint involvement in acute rheumatic fever.

http://www.jped.com.br/conteudo/00-76-01-49/ing.pdf

Kissing balloon is the standard technique used to tackle   branch vessel stenosis . When a vessel branches out and both branches has a lesion,  single balloon can not dilate a lesion optimally . This  is  because , the side branch  not only shares a common ostial tissue but also  shares  plaque material within the walls of main and side  vessel . Dilating one vessel alone could result in unpredictable plaque shift.

Carina is the most important anatomic structure in a bifurcation zone . It acts like a grade separator. Diverting and deflecting blood flow .The  length and angle of this grade separator determine the ostial  shape as well . A right angled side branch will have  a circular ostium .An acute-angled branch  will have oval orifice .  The plaque burden and distributions at this point becomes vital for many reasons.

When we do PCI this carinal area should be  optimally pressed and plastied  and of course covered well with the metal struts.The  simultaneous kissing with two balloons ,  one in main vessel another in side branch will reduce many of the issues . This area is a weak link for interventional cardiologists. It needs lots of efforts to protect the side vessel.

When do we do kissing balloon ?

Two broad categories.

  • Pre-dilatation and preparing a lesion ( Not routine  )
  • Post dilatation is more often done .

Look closely the layers of contention in the carinal zone. Lesion not depicted .

Kissing interface : When the balloons kiss  what lies  in between ?

  1. Simple  Balloon to Balloon Kissing with nothing intervening(Proximal to branch point )
  2. Balloon- Single layer of Stent-balloon kissing
  3. Carinal  Kissing -Balloon -Two layers of Carinal tissue -one layer of Stent -Balloon Kissing ( See above image )
  4. Twin stent kissing

When do  balloons refuse to Kiss ?

When there is a hard interface between the vessels like a severely  calcified intima /Adventia .

Eccentric /overhanging  lesions intervening.

Incomplete kiss

It need to be emphasized balloons come  into contact easily in  acute-angled lesions.

In right  angled lesions the balloons come to contact only in the proximal part.

Definite indications  for  kissing ?

Kissing is not without complications . While two guide wires are placed in all  bifurcation lesions  , kissing is  not necessary in many  lesions  .Of course it is a must in all true bifurcation lesions (Medina 111 , 011, 101, )  It may not be required in  1,0,0 if carina is away from lesion.

*Kissing can rarely aggravate the same issue which is supposed to prevent  ie plaque shift .This is due to differential pressure transmission by two balloons.

Is there a role for  twin balloon POBA  without any stenting ?

Most cardiologists would not believe  in POBA anyore (For wrong reasons though ! )

A distal RCA with a PDA ostial branch lesion could be tackled with twin balloon POBA.

Which  balloon is to be used?

It depends on whether we use the technique  as POBA, single stent or double stent technique. Non compliant balloons are  ideal  as it exerts   more pressure on the vessel wall .

Kissing   at  what  pressure ?

The pressure used is often between 8-14 ATM.

Experts may use differential pressure inflation depending on the lesion characters.

Which  is the Most complex form of kissing ?  

Two stents, two balloons . Here the interface contains two metal layers . At carnia the two metals engulf   two layers of  tissue as well .

Final message

Bifurcation lesions  are being  conquered with more success in recent years.

The techniques have refined. Stent designs and drug eluting stents  are  helping us in many ways.

We have learnt  from our  mistakes and accepted the limitations.

Wisdom  prevails now , there is a universal consensus  for less  metal in the notorious  carinal  area.

Still, ignorance  remains*  as  a major  guiding force   . . . when  we  navigate  the difficult atheromatous terrains  in  live human  coronary arteries !

*With due respects to IVUS, OCT and FFR .

**Forward looking IVUS, and camera tipped guidewires may change the scenerio.

 

Further reading

What-is-the-simple-approach-to-bifurcation-pci ?


Here is an X-ray of classical rheumatic mitral stenois with a mitral orifice of  .8 square cm.

Why the left heart border is straight in mitral stenosis ?

It is due to 4 factors.

  1. Hypoplastic aorta
  2. LAA
  3. PA
  4. Under filled LV

Note :

  • This straightening occurs   only  in  isolated , severe forms of mitral stenosis  as it requires under filling of left  ventricle   and Aorta.
  • Significant mitral regurgitation will lift the lower end of straight line .
  • In associated aortic valve lesions especially in aortic regurgitation the straightening can not occur as LV and  Aorta continues  to be conspicuous.
  • If mitral stenosis  causes severe PAH and tricuspid regurgitation , RV  can  become  huge  and form the left heart border and distort the straight line.

Amiodarone acts  by

  1. Correcting the  rhythm  to sinus .
  2. Controls  ventricular rate  alone
  3. Does both ?

Answer is 3

How can it correct the rhythm alone ?  If  the rhythm is corrected ,  rate will automatically be controlled,  unless Amiodarone converts AF into Sinus tachycardia  which is very unlikely !

Of course  Amidarone  is not a  magic drug .The success rate of  Amiodarone  restoring  sinus rhythm is far . . . far less . . . than our expectations ! . It fails to  convert to sinus rhythm in a significant chunk *. Interestingly ,   it may still  control the  ventricular response  by its beta blocking action .

*Our estimate is , the failure rate Amiodarone  is  between  30-40%  or even higher ,  as   bulk of AF we witness   is due to Rheumatic heart disease.